DOAJ Open Access 2024

Heterogeneity and subtypes of CD4+ regulatory T cells: implications for tumor therapy

Hanqing Lin Hanqing Lin Yuanteng Xu Yuanteng Xu Chang Lin +1 lainnya

Abstrak

In the conventional view, CD4+ regulatory T cell (Treg) represents a subset of lymphocytes that involve the perception and negative regulation of the immune response. CD4+Treg plays an important role in the maintenance of immune homeostasis and immune tolerance. However, recent studies have revealed that CD4+Treg do not suppress the immune response in some diseases, but promote inflammatory injury or inhibit tissue remodeling, suggesting the functional heterogeneity of CD4+Treg. Their involvement in tumor pathogenesis is more complex than previously understood. This article reviews the relevant research on the heterogeneity of CD4+Treg, subtype classification, and their relationship with tumor therapy.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (6)

Hanqing Lin

Yuanteng Xu

Chang Lin

Format Sitasi

APA MLA BibTeX

Lin, H., Lin, H., Xu, Y., Xu, Y., Lin, C., Lin, C. (2024). Heterogeneity and subtypes of CD4+ regulatory T cells: implications for tumor therapy. https://doi.org/10.3389/fimmu.2023.1291796

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Informasi Jurnal

Tahun Terbit: 2024
Sumber Database: DOAJ
DOI: 10.3389/fimmu.2023.1291796
Akses: Open Access ✓