DOAJ Open Access 2023

The central inflammatory regulator IκBζ: induction, regulation and physiological functions

Yanpeng Feng Zhiyuan Chen Yi Xu Yuxuan Han Xiujuan Jia +4 lainnya

Abstrak

IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors in the NF-KB pathway, thereby affecting the progression of related diseases. In recent years, investigations into NFKBIZ have led to greater understanding of this gene. In this review, we summarize the induction of NFKBIZ and then elucidate its transcription, translation, molecular mechanism and physiological function. Finally, the roles played by NFKBIZ in psoriasis, cancer, kidney injury, autoimmune diseases and other diseases are described. NFKBIZ functions are universal and bidirectional, and therefore, this gene may exert a great influence on the regulation of inflammation and inflammation-related diseases.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (9)

Yanpeng Feng

Zhiyuan Chen

Yi Xu

Yuxuan Han

Xiujuan Jia

Zixuan Wang

Nannan Zhang

Wenjing Lv

Format Sitasi

APA MLA BibTeX

Feng, Y., Chen, Z., Xu, Y., Han, Y., Jia, X., Wang, Z. et al. (2023). The central inflammatory regulator IκBζ: induction, regulation and physiological functions. https://doi.org/10.3389/fimmu.2023.1188253

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.3389/fimmu.2023.1188253
Akses: Open Access ✓