DOAJ Open Access 2022

Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease

Matteo Doglio Rachel E. Crossland Ana C. Alho Ana C. Alho Olaf Penack +9 lainnya

Abstrak

Hematopoietic allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with hematological malignancies. However, due to disparities in major and minor histocompatibility antigens between donor and recipient, severe inflammatory complications can occur, among which chronic graft-versus-host disease (cGVHD) can be life-threatening. A classical therapeutic approach to the prevention and treatment of cGVHD has been broad immunosuppression, but more recently adjuvant immunotherapies have been tested. This review summarizes and discusses immunomodulatory approaches with T cells, including chimeric antigen receptor (CAR) and regulatory T cells, with natural killer (NK) cells and innate lymphoid cells (ILCs), and finally with mesenchymal stromal cells (MSC) and extracellular vesicles thereof. Clinical studies and pre-clinical research results are presented likewise.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (14)

Matteo Doglio

Rachel E. Crossland

Ana C. Alho

Olaf Penack

Anne M. Dickinson

Georg Stary

João F. Lacerda

Günther Eissner

Marit Inngjerdingen

Format Sitasi

APA MLA BibTeX

Doglio, M., Crossland, R.E., Alho, A.C., Alho, A.C., Penack, O., Dickinson, A.M. et al. (2022). Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease. https://doi.org/10.3389/fimmu.2022.1045168

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.3389/fimmu.2022.1045168
Akses: Open Access ✓