Enhanced Spike-specific, but attenuated Nucleocapsid-specific T cell responses upon SARS-CoV-2 breakthrough versus non-breakthrough infections
Abstrak
SARS-CoV-2 vaccine breakthrough infections frequently occurred even before the emergence of Omicron variants. Yet, relatively little is known about the impact of vaccination on SARS-CoV-2-specific T cell and antibody response dynamics upon breakthrough infection. We have therefore studied the dynamics of CD4 and CD8 T cells targeting the vaccine-encoded Spike and the non-encoded Nucleocapsid antigens during breakthrough infections (BTI, n=24) and in unvaccinated control infections (non-BTI, n=30). Subjects with vaccine breakthrough infection had significantly higher CD4 and CD8 T cell responses targeting the vaccine-encoded Spike during the first and third/fourth week after PCR diagnosis compared to non-vaccinated controls, respectively. In contrast, CD4 T cells targeting the non-vaccine encoded Nucleocapsid antigen were of significantly lower magnitude in BTI as compared to non-BTI. Hence, previous vaccination was linked to enhanced T cell responses targeting the vaccine-encoded Spike antigen, while responses against the non-vaccine encoded Nucleocapsid antigen were significantly attenuated.
Topik & Kata Kunci
Penulis (30)
Mohamed Ibraheem Mahmoud Ahmed
Mohamed Ibraheem Mahmoud Ahmed
Paulina Diepers
Christian Janke
Michael Plank
Tabea M. Eser
Tabea M. Eser
Raquel Rubio-Acero
Anna Fuchs
Olga Baranov
Olga Baranov
Noemi Castelletti
Inge Kroidl
Inge Kroidl
Laura Olbrich
Laura Olbrich
Laura Olbrich
Bernadette Bauer
Danni Wang
Martina Prelog
Johannes G. Liese
Christina Reinkemeyer
Michael Hoelscher
Michael Hoelscher
Philipp Steininger
Klaus Überla
Andreas Wieser
Andreas Wieser
Christof Geldmacher
Christof Geldmacher
Format Sitasi
Akses Cepat
- Tahun Terbit
- 2022
- Sumber Database
- DOAJ
- DOI
- 10.3389/fimmu.2022.1026473
- Akses
- Open Access ✓