DOAJ Open Access 2022

A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients

Claire Tardiveau Claire Tardiveau Guillaume Monneret Guillaume Monneret Anne-Claire Lukaszewicz +35 lainnya

Abstrak

Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex transcriptomic panel prototype termed Immune Profiling Panel (IPP) could capture the dysregulation of immune responses of ICU COVID-19 patients at admission. Nine transcripts were associated with mortality in univariate analysis and this 9-mRNA signature remained significantly associated with mortality in a multivariate analysis that included age, SOFA and Charlson scores. Using a machine learning model with these 9 mRNA, we could predict the 28-day survival status with an Area Under the Receiver Operating Curve (AUROC) of 0.764. Interestingly, adding patients’ age to the model resulted in increased performance to predict the 28-day mortality (AUROC reaching 0.839). This prototype IPP demonstrated that such a tool, upon clinical/analytical validation and clearance by regulatory agencies could be used in clinical routine settings to quickly identify patients with higher risk of death requiring thus early aggressive intensive care.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (40)

Claire Tardiveau

Guillaume Monneret

Anne-Claire Lukaszewicz

Valérie Cheynet

Elisabeth Cerrato

Katia Imhoff

Estelle Peronnet

Maxime Bodinier

Louis Kreitmann

Sophie Blein

Jean-François Llitjos

Filippo Conti

Morgane Gossez

Marielle Buisson

Hodane Yonis

Martin Cour

Laurent Argaud

Marie-Charlotte Delignette

Florent Wallet

Frederic Dailler

Céline Monard

Karen Brengel-Pesce

Fabienne Venet

the RICO study group

Format Sitasi

APA MLA BibTeX

Tardiveau, C., Tardiveau, C., Monneret, G., Monneret, G., Lukaszewicz, A., Lukaszewicz, A. et al. (2022). A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients. https://doi.org/10.3389/fimmu.2022.1022750

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.3389/fimmu.2022.1022750
Akses: Open Access ✓