DOAJ Open Access 2021

Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells

Jingli Lu Jingli Lu Jingli Lu Yan Liang Yan Liang +11 lainnya

Abstrak

Forkhead box protein 3 (Foxp3+)-expressing regulatory T (Treg) cells are a unique CD4+T cell subset that suppresses excessive immune responses. The epigenetic plasticity and metabolic traits of Treg cells are crucial for the acquisition of their phenotypic and functional characteristics. Therefore, alterations to the epigenetics and metabolism affect Treg cell development and function. Recent evidence reveals that altering the metabolic pathways and generation of metabolites can regulate the epigenetics of Treg cells. Specifically, some intermediates of cell metabolism can directly act as substrates or cofactors of epigenetic-modifying enzymes. Here, we describe the metabolic and epigenetic features during Treg cell development, and discuss how metabolites can contribute to epigenetic alterations of Treg cells, which affects Treg cell activation, differentiation, and function.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (16)

Jingli Lu

Yan Liang

Haiyang Meng

Ailing Zhang

Junjie Zhao

Chengliang Zhang

Format Sitasi

APA MLA BibTeX

Lu, J., Lu, J., Lu, J., Liang, Y., Liang, Y., Liang, Y. et al. (2021). Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells. https://doi.org/10.3389/fimmu.2021.728783

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Informasi Jurnal

Tahun Terbit: 2021
Sumber Database: DOAJ
DOI: 10.3389/fimmu.2021.728783
Akses: Open Access ✓