Comprehensive Analysis of Myeloid Signature Genes in Head and Neck Squamous Cell Carcinoma to Predict the Prognosis and Immune Infiltration
Abstrak
Myeloid cells are a major heterogeneous cell population in the tumor immune microenvironment (TIME). Imbalance of myeloid response remains a major obstacle to a favorable prognosis and successful immune therapy. Therefore, we aimed to construct a risk model to evaluate the myeloid contexture, which may facilitate the prediction of prognosis and immune infiltration in patients with head and neck squamous cell carcinoma (HNSCC). In our study, six myeloid signature genes (including CCL13, CCR7, CD276, IL1B, LYVE1 and VEGFC) analyzed from 52 differentially expressed myeloid signature genes were finally pooled to establish a prognostic risk model, termed as myeloid gene score (MGS) in a training cohort and validated in a test cohort and an independent external cohort. Furthermore, based on the MGS subgroups, we were able to effectively identify patients with a poor prognosis, aggressive clinical parameters, immune cell infiltration status and immunotherapy response. Thus, MGS may serve as an effective prognostic signature and predictive indicator for immunotherapy response in patients with HNSCC.
Topik & Kata Kunci
Penulis (36)
Zhifeng Liu
Zhifeng Liu
Zhifeng Liu
Zhifeng Liu
Diekuo Zhang
Diekuo Zhang
Diekuo Zhang
Chao Liu
Chao Liu
Chao Liu
Guo Li
Guo Li
Guo Li
Huihong Chen
Huihong Chen
Huihong Chen
Hang Ling
Hang Ling
Hang Ling
Fengyu Zhang
Fengyu Zhang
Fengyu Zhang
Donghai Huang
Donghai Huang
Donghai Huang
Xingwei Wang
Xingwei Wang
Xingwei Wang
Yong Liu
Yong Liu
Yong Liu
Yong Liu
Xin Zhang
Xin Zhang
Xin Zhang
Xin Zhang
Akses Cepat
- Tahun Terbit
- 2021
- Sumber Database
- DOAJ
- DOI
- 10.3389/fimmu.2021.659184
- Akses
- Open Access ✓