DOAJ Open Access 2023

The role of glucagon after bariatric/metabolic surgery: much more than an “anti-insulin” hormone

Gonzalo-Martín Pérez-Arana Gonzalo-Martín Pérez-Arana Alfredo Díaz-Gómez José Bancalero-de los Reyes Manuel Gracia-Romero +8 lainnya

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Abstrak

The biological activity of glucagon has recently been proposed to both stimulate hepatic glucose production and also include a paradoxical insulinotropic effect, which could suggest a new role of glucagon in the pathophysiology type 2 diabetes mellitus (T2DM). An insulinotropic role of glucagon has been observed after bariatric/metabolic surgery that is mediated through the GLP-1 receptor on pancreatic beta cells. This effect appears to be modulated by other members of the proglucagon family, playing a key role in the beneficial effects and complications of bariatric/metabolic surgery. Glucagon serves a dual role after sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). In addition to maintaining blood glucose levels, glucagon exhibits an insulinotropic effect, suggesting that glucagon has a more complex function than simply an “anti-insulin hormone”.

Topik & Kata Kunci

Diseases of the endocrine glands. Clinical endocrinology

Penulis (13)

Gonzalo-Martín Pérez-Arana

Alfredo Díaz-Gómez

José Bancalero-de los Reyes

Manuel Gracia-Romero

Antonio Ribelles-García

Francisco Visiedo

Álvaro González-Domínguez

David Almorza-Gomar

José-Arturo Prada-Oliveira

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APA MLA BibTeX

Pérez-Arana, G., Pérez-Arana, G., Díaz-Gómez, A., Reyes, J.B.l., Gracia-Romero, M., Ribelles-García, A. et al. (2023). The role of glucagon after bariatric/metabolic surgery: much more than an “anti-insulin” hormone. https://doi.org/10.3389/fendo.2023.1236103

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.3389/fendo.2023.1236103
Akses: Open Access ✓