DOAJ Open Access 2021

Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology

Livia Odagiu Livia Odagiu Julia May Salix Boulet Troy A. Baldwin +3 lainnya

Abstrak

The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes that are induced by various signals. They act as transcription factors and their activity is not regulated by ligand binding and are thus regulated via their expression levels. Their expression is transiently induced in T cells by triggering of the T cell receptor following antigen recognition during both thymic differentiation and peripheral T cell responses. In this review, we will discuss how NR4A family members impact different aspects of the life of a T cell from thymic differentiation to peripheral response against infections and cancer.

Topik & Kata Kunci

Diseases of the endocrine glands. Clinical endocrinology

Penulis (8)

Livia Odagiu

Julia May

Salix Boulet

Troy A. Baldwin

Nathalie Labrecque

Format Sitasi

APA MLA BibTeX

Odagiu, L., Odagiu, L., May, J., Boulet, S., Baldwin, T.A., Labrecque, N. et al. (2021). Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology. https://doi.org/10.3389/fendo.2020.624122

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Informasi Jurnal

Tahun Terbit: 2021
Sumber Database: DOAJ
DOI: 10.3389/fendo.2020.624122
Akses: Open Access ✓