DOAJ Open Access 2017

A Robust and Efficient Numerical Method for RNA-Mediated Viral Dynamics

Vladimir Reinharz Alexander Churkin Harel Dahari Danny Barash

Abstrak

The multiscale model of hepatitis C virus (HCV) dynamics, which includes intracellular viral RNA (vRNA) replication, has been formulated in recent years in order to provide a new conceptual framework for understanding the mechanism of action of a variety of agents for the treatment of HCV. We present a robust and efficient numerical method that belongs to the family of adaptive stepsize methods and is implicit, a Rosenbrock type method that is highly suited to solve this problem. We provide a Graphical User Interface that applies this method and is useful for simulating viral dynamics during treatment with anti-HCV agents that act against HCV on the molecular level.

Topik & Kata Kunci

Applied mathematics. Quantitative methods Probabilities. Mathematical statistics

Penulis (4)

Vladimir Reinharz

Alexander Churkin

Harel Dahari

Danny Barash

Format Sitasi

APA MLA BibTeX

Reinharz, V., Churkin, A., Dahari, H., Barash, D. (2017). A Robust and Efficient Numerical Method for RNA-Mediated Viral Dynamics. https://doi.org/10.3389/fams.2017.00020

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Informasi Jurnal

Tahun Terbit: 2017
Sumber Database: DOAJ
DOI: 10.3389/fams.2017.00020
Akses: Open Access ✓