Otologic Manifestation in IgG4-Related Systemic Disease
Abstrak
IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-year-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate.
Topik & Kata Kunci
Penulis (4)
Han-Kyu Cho
Yun Jong Lee
Jin-Haeng Chung
Ja-Won Koo
Akses Cepat
- Tahun Terbit
- 2011
- Sumber Database
- DOAJ
- DOI
- 10.3342/ceo.2011.4.1.52
- Akses
- Open Access ✓