Male sex adversely impacts survival and myeloid malignancy risk in MGUS: a real-world population-based study
Abstrak
Monoclonal gammopathy of undetermined significance (MGUS) is a common plasma cell disorder with well described risks of progression to myeloma and lymphoplasmacytic lymphoma. Using data from an established UK population-based cohort of haematological malignancies and premalignancies, we investigated patient and disease characteristics, subsequent haematological malignancy, and survival in 4651 people diagnosed with MGUS 2005-2019. The 5-year net (relative) survival (disease-specific estimate of the probability of survival) of MGUS patients was 87.8% (95% Confidence Interval 85.9-89.7), with males (83.8%; 95% CI 81.0-86.6) more affected than females (92.2%; 95% CI 89.7-94.7). The proportion of subsequent haematological malignancies was also higher in males than females (8.8% versus 5.3%; P
Topik & Kata Kunci
Penulis (14)
Eve Roman
Timothy Bagguley
Simon Crouch
Alexandra Smith
Daniel Painter
Debra Howell
Russell Patmore
Reuben Tooze
Catherine Cargo
Ruth De Tute
Andrew Rawstron
Gordon Cook
Christopher Parrish
Frances Seymour
Akses Cepat
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Cek di sumber asli →- Tahun Terbit
- 2026
- Sumber Database
- DOAJ
- DOI
- 10.3324/haematol.2025.289200
- Akses
- Open Access ✓