Revised renal stratification and progression models for predicting long-term renal outcomes in immunoglobulin light chain amyloidosis
Abstrak
Renal prognosis in light-chain amyloidosis (AL) is determined by categorizing patients into three renal stages at diagnosis and assessing Renal Response or Renal Progression following chemotherapy after 6 months. We evaluated, in a test (N=1935) cohort of patients with renal AL amyloidosis who were followed for a median of 95 months, a modified 4-stage model where Renal Stage 2 was sub-categorized according to preserved (2A) or reduced (2B) estimated Glomerular Filtration Rate (eGFR). A hybrid model for evaluation of Renal Progression was also introduced, using an eGFR cut-off of 30ml/min/1.73 m2. These models were compared with existing models; namely those of Palladini and Kastritis, and results were validated in a multicenter cohort (N=438). The risk of progression to renal replacement therapy (RRT) increased progressively across all Renal Stages of the revised staging model (Hazard ratio [HR]: 3.25, 5.13, 10.66 for Stages 2A, 2B and 3 respectively vs Stage 1, each p
Topik & Kata Kunci
Penulis (29)
Muhammad Umaid Rauf
Steven Law
Marisa Santostefano
Philip N. Hawkins
Aviva Petrie
Francesco Cappelli
Federico Perfetto
Yousuf Razvi
Aldostefano Porcari
Sriram Ravichandran
Adam Ioannou
Joshua Bomsztyk
Alessia Argirò
Costanza Gaudio
Elisabetta Antonioli
Alessandro Barilaro
Marco Delsante
Vittorio Di Maso
Maria G. Chiappini
Olabisi Ogunbiyi
Oliver C. Cohen
Ana Martinez-Naharro
Carol Whelan
Helen J. Lachmann
Ashutosh D. Wechalekar
Federico Alberici
Marianna Fontana
Marco Allinovi
Julian D. Gillmore
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Cek di sumber asli →- Tahun Terbit
- 2025
- Sumber Database
- DOAJ
- DOI
- 10.3324/haematol.2025.287703
- Akses
- Open Access ✓