Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B-cell lymphoma
Abstrak
Enhancers are regulatory regions of DNA, which play a key role in cell-type specific differentiation and development. Most active enhancers are transcribed into enhancer RNA (eRNA) that can regulate transcription of target genes by means of in cis as well as in trans action. eRNA stabilize contacts between distal genomic regions and mediate the interaction of DNA with master transcription factors. Here, we characterized an enhancer eRNA, GECPAR (germinal center proliferative adapter RNA), which is specifically transcribed in normal and neoplastic germinal center B cells from the super-enhancer of POU2AF1, a key regulatory gene of the germinal center reaction. Using diffuse large B-cell lymphoma cell line models, we demonstrated the tumor suppressor activity of GECPAR, which is mediated via its transcriptional regulation of proliferation and differentiation genes, particularly MYC and the Wnt pathway.
Topik & Kata Kunci
Penulis (18)
Sara Napoli
Luciano Cascione
Andrea Rinaldi
Filippo Spriano
Francesca Guidetti
Fangwen Zhang
Maria Teresa Cacciapuoti
Afua Adjeiwaa Mensah
Giulio Sartori
Nicolas Munz
Mattia Forcato
Silvio Bicciato
Annalisa Chiappella
Paola Ghione
Olivier Elemento
Leandro Cerchietti
Giorgio Inghirami
Francesco Bertoni
Akses Cepat
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Cek di sumber asli →- Tahun Terbit
- 2021
- Sumber Database
- DOAJ
- DOI
- 10.3324/haematol.2020.267096
- Akses
- Open Access ✓