DOAJ Open Access 2019

Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions

Peter Valent Attilio Orazi Michael R. Savona Mrinal M. Patnaik Francesco Onida +25 lainnya

Abstrak

Chronic myelomonocytic leukemia (CMML) is a myeloid neoplasm characterized by dysplasia, abnormal production and accumulation of monocytic cells and an elevated risk of transforming into acute leukemia. Over the past two decades, our knowledge about the pathogenesis and molecular mechanisms in CMML has increased substantially. In parallel, better diagnostic criteria and therapeutic strategies have been developed. However, many questions remain regarding prognostication and optimal therapy. In addition, there is a need to define potential pre-phases of CMML and special CMML variants, and to separate these entities from each other and from conditions mimicking CMML. To address these unmet needs, an international consensus group met in a Working Conference in August 2018 and discussed open questions and issues around CMML, its variants, and pre-CMML conditions. The outcomes of this meeting are summarized herein and include diag nostic criteria and a proposed classification of pre-CMML conditions as well as refined minimal diagnostic criteria for classical CMML and special CMML variants, including oligomonocytic CMML and CMML associated with systemic mastocytosis. Moreover, we propose diagnostic standards and tools to distinguish between ‘normal’, pre-CMML and CMML entities. These criteria and standards should facilitate diagnostic and prognostic evaluations in daily practice and clinical studies in applied hematology.

Topik & Kata Kunci

Diseases of the blood and blood-forming organs

Penulis (30)

Peter Valent

Attilio Orazi

Michael R. Savona

Mrinal M. Patnaik

Francesco Onida

Arjan A. van de Loosdrecht

Detlef Haase

Torsten Haferlach

Chiara Elena

Lisa Pleyer

Wolfgang Kern

Tea Pemovska

Gregory I. Vladimer

Julie Schanz

Alexandra Keller

Michael Lübbert

Thomas Lion

Karl Sotlar

Andreas Reiter

Theo De Witte

Michael Pfeilstöcker

Klaus Geissler

Eric Padron

Michael Deininger

Alberto Orfao

Hans-Peter Horny

Peter L. Greenberg

Daniel A. Arber

Luca Malcovati

John M. Bennett

Format Sitasi

APA MLA BibTeX

Valent, P., Orazi, A., Savona, M.R., Patnaik, M.M., Onida, F., Loosdrecht, A.A.v.d. et al. (2019). Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions. https://doi.org/10.3324/haematol.2019.222059

Akses Cepat

PDF tidak tersedia langsung

Cek di sumber asli →

Lihat di Sumber doi.org/10.3324/haematol.2019.222059

Informasi Jurnal

Tahun Terbit: 2019
Sumber Database: DOAJ
DOI: 10.3324/haematol.2019.222059
Akses: Open Access ✓