DOAJ Open Access 2007

From brain to testis: immune escape and clonal selection in a B cell lymphoma with selective out-growth in two immune sanctuariesy

Marije Booman Jenny Douwes Marie-Cecile Legdeur Joop van Baarlen Ed Schuuring +1 lainnya

Abstrak

We describe a patient with a primary diffuse large B-cell lymphoma of the central nervous system who developed a localized testicular relapse after 8 years. Both tumours lacked HLA-DR expression, the relapse additionally lost HLA class I expression. Immunoglobulin heavy chain gene rearrangements were identical in both lymphomas with extensive and ongoing somatic hypermutations resulting in extensive idiotype modulation. We hypothesize that these immune sanctuaries initially provided a safe haven for the tumour cells. When the environment becomes more permissive for an anti-tumour response, the continuous idiotype modulation and progressive loss of HLA expression on the tumour cells facilitates further immune escape.

Topik & Kata Kunci

Diseases of the blood and blood-forming organs

Penulis (6)

Marije Booman

Jenny Douwes

Marie-Cecile Legdeur

Joop van Baarlen

Ed Schuuring

Philip Kluin

Format Sitasi

APA MLA BibTeX

Booman, M., Douwes, J., Legdeur, M., Baarlen, J.v., Schuuring, E., Kluin, P. (2007). From brain to testis: immune escape and clonal selection in a B cell lymphoma with selective out-growth in two immune sanctuariesy. https://doi.org/10.3324/haematol.11421

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Informasi Jurnal

Tahun Terbit: 2007
Sumber Database: DOAJ
DOI: 10.3324/haematol.11421
Akses: Open Access ✓