Analysis of some trends of the pharmaceutical market of rodenticides in Ukraine and the peculiarities of their use for deratization

One of the most relevant zoocides are rodenticides used to control harmful rodents. Carrying out effective deratization measures on the territory of Ukraine is especially important nowadays during the Russian-Ukrainian war. According to the reports of Ukrainian servicemen and civilians in the de-occupied territories, the population of rodents is extremely large, and not all modern rodenticide drugs lead to the death of harmful animals of these species. However, the toxicological characteristics of rodenticides take into account the fact that they can poison non-target animals. The purpose of our study was to analyze the pharmaco-toxicological characteristics of rodenticides and the main trends in the pharmaceutical market of drugs of this group registered in Ukraine as of January 1, 2024. It has been established that bromadiolone (77 %) and brodifacoum (23 %) are the main active substances in modern deratization agents. They belong to second-generation anticoagulants with a chronic mechanism of action. All registered rodenticides are produced in Ukraine and are available in various dosage forms. The low effectiveness of rodenticides can be due to falsification of starting substances for the synthesis of rodenticides, inconsistency of the required content of active substances, development of resistance of rodents to poisonous substances, etc. It is expected that the results highlighted in the article will indicate further directions in the development of new rodenticides and/or increase the effectiveness of the generally accepted scheme of deratization. In Ukraine, in the conditions of the Russian-Ukrainian war and in the post-war period, these questions are among the most significant, which scientists, pharmacologists and toxicologists, pharmacists and industry manufacturers should work on.