DOAJ Open Access 2025

CCNE1 EXPRESSION AND CA-125 LEVELS IN HIGH GRADE SEROUS CARCINOMA OVARY AT MOHAMMAD HOESIN HOSPITAL PALEMBANG ; A SINGLE-INSTITUTION DESCRIPTIVE STUDY

Dianli Fitriani Wresnindyatsih Susilawati

Abstrak

High grade serous carcinoma (HGSC) of the ovary is the dominant subtype causing death from ovarian cancer. CCNE1 amplification occurs in 20% of ovarian HGSC and is associated with recurrence after platinum chemotherapy. Assessment of CCNE1 expression can be a screening for CCNE1 amplification. Measurement of CA-125 levels is routinely used for treatment monitoring and recurrence of HGSC patients. This study aims to assess CCNE1 expression, demographic characteristics and CA-125 levels of ovarian HGSC patients. Of the 31 HGSC patients, the study subjects were dominated by patients aged >50 years (61.3%), clinical stage FIGO III (64.5%), CCNE1 overexpression (71%), preoperative CA-125 levels ≥500 U/ml (77.4%) and postchemotherapy CA-125 levels <35 U/ml (58.1%).

Topik & Kata Kunci

Medicine

Penulis (3)

Dianli Fitriani

Wresnindyatsih

Susilawati

Format Sitasi

APA MLA BibTeX

Fitriani, D., Wresnindyatsih, Susilawati (2025). CCNE1 EXPRESSION AND CA-125 LEVELS IN HIGH GRADE SEROUS CARCINOMA OVARY AT MOHAMMAD HOESIN HOSPITAL PALEMBANG ; A SINGLE-INSTITUTION DESCRIPTIVE STUDY. https://doi.org/10.32539/jkk.v12i2.671

Akses Cepat

PDF tidak tersedia langsung

Cek di sumber asli →

Lihat di Sumber doi.org/10.32539/jkk.v12i2.671

Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.32539/jkk.v12i2.671
Akses: Open Access ✓