DOAJ Open Access 2024

Research Progress on the Mechanism of Lysosome in Myocardial Ischemia-Reperfusion Injury Based on Autophagy

Yi Li Hui Wu Songlin Zhang Gang Zhou Dong Zhang +3 lainnya

Abstrak

In recent years, the interaction of intracellular organelles such as mitochondria and lysosomal functions has attracted increasing attention. Recent evidence suggests that mitochondrion-lysosomal contact plays a key role in regulating lysosomal biogenesis and maintaining cellular homeostasis. Myocardial ischemia and reperfusion will lead to corresponding changes in the autophagy flux in cardiomyocytes, and lysosomes are a key link in the process of autophagy, and the fusion of lysosomes and autophagosomes is an essential link in the occurrence of autophagy. Therefore, the function and homeostasis of lysosomes also undergo different changes during myocardial ischemia and reperfusion. Lysosomal-related biological factors and membrane proteins also play different roles. This article will review the mechanism of lysosomes in myocardial ischemia-reperfusion injury and the research progress of lysosomal-related proteins.

Topik & Kata Kunci

Diseases of the circulatory (Cardiovascular) system

Penulis (8)

Yi Li

Hui Wu

Songlin Zhang

Gang Zhou

Dong Zhang

Qingzhuo Yang

Yanfang Liu

Xiaoli Huang

Format Sitasi

APA MLA BibTeX

Li, Y., Wu, H., Zhang, S., Zhou, G., Zhang, D., Yang, Q. et al. (2024). Research Progress on the Mechanism of Lysosome in Myocardial Ischemia-Reperfusion Injury Based on Autophagy. https://doi.org/10.31083/j.rcm2504113

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Informasi Jurnal

Tahun Terbit: 2024
Sumber Database: DOAJ
DOI: 10.31083/j.rcm2504113
Akses: Open Access ✓