Determination of prilocaine HCl in bulk drug and pharmaceutical formulation by GC-NPD method
Abstrak
The novel analytical method was developed and validated for determination of prilocaine HCl in bulk drug and pharmaceutical formulation by gas chromatography-nitrogen phosphorus detection (GC-NPD). The chromatographic separation was performed using a HP-5MS column. The calibration curve was linear over the concentration range of 40-1000 ng ml-1 with a correlation coefficient of 0.9998. The limits of detection (LOD) and quantification (LOQ) of method were 10 ng ml-1 and 35 ng ml-1, respectively. The within-day and between-day precision, expressed as the percent relative standard deviation (RSD%) was less than 5.0%, and accuracy (percent relative error) was better than 4.0%. The developed method can be directly and easily applied for determination of prilocaine HCl in bulk drug and pharmaceutical formulation using internal standard methodology.
Topik & Kata Kunci
Penulis (2)
Atila Alptug
Kadioglu Yucel
Akses Cepat
- Tahun Terbit
- 2013
- Sumber Database
- DOAJ
- DOI
- 10.2298/CICEQ120124064A
- Akses
- Open Access ✓