Pharmacotherapy and analysis of gaseous mediators in hypertensive patients
Abstrak
OBJECTIVE To evaluate the effect of using antihypertensive classes of drugs of the calcium channel antagonists and inhibitors of angiotensin-converting enzyme in plasma concentrations of hydrogen sulfide and nitric oxide in patients with hypertension. METHODS Cross-sectional study with quantitative approach conducted with hypertensive patients in use of antihypertensive classes of drugs: angiotensin-converting enzyme inhibitors or calcium channel antagonists. RESULTS It was found that the concentration of plasma nitric oxide was significantly higher in hypertensive patients that were in use of angiotensin-converting enzyme inhibitors (p<0.03) and the hydrogen sulphide concentration was significantly higher in hypertensive plasma in use of calcium channel antagonists (p<0.002). CONCLUSION The findings suggest that these medications have as additional action mechanism the improvement of endothelial dysfunction by elevate plasma levels of vasodilatory substances.
Topik & Kata Kunci
Penulis (5)
Letícia Palota Eid
Renato Nery Soriano
Marcelo Eduardo Batalhão
Lais Palotta Balderrama
Evelin Capellari Carnio
Akses Cepat
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- 2015
- Sumber Database
- DOAJ
- DOI
- 10.1590/S0080-623420150000100009
- Akses
- Open Access ✓