DOAJ Open Access 2014

Antioxidant protection of statins in acute kidney injury induced by sepsis

Franciele do Nascimento Santos Mirian Watanabe Carolina Ferreira Vasco Cassiane Dezoti da Fonseca Maria de Fatima Fernandes Vattimo

Lihat Sumber DOI

Abstrak

Objective Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis. Method Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation – CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity of acute kidney injury and animal survival were evaluated. Results The treatment with simvastatin in induced sepsis showed elevation of creatinine clearance with attenuation of generation of oxidative metabolites, lower severity of acute kidney injury and reduced mortality. Conclusion This investigation confirmed the renoprotection with antioxidant principle of the simvastatin in acute kidney injury induced by sepsis in an experimental model.

Topik & Kata Kunci

Public aspects of medicine Nursing Mental healing Education (General)

Penulis (5)

Franciele do Nascimento Santos

Mirian Watanabe

Carolina Ferreira Vasco

Cassiane Dezoti da Fonseca

Maria de Fatima Fernandes Vattimo

Format Sitasi

APA MLA BibTeX

Santos, F.d.N., Watanabe, M., Vasco, C.F., Fonseca, C.D.d., Vattimo, M.d.F.F. (2014). Antioxidant protection of statins in acute kidney injury induced by sepsis. https://doi.org/10.1590/S0080-6234201400005000007

Akses Cepat

PDF tidak tersedia langsung

Cek di sumber asli →

Lihat di Sumber doi.org/10.1590/S0080-6234201400005000007

Informasi Jurnal

Tahun Terbit: 2014
Sumber Database: DOAJ
DOI: 10.1590/S0080-6234201400005000007
Akses: Open Access ✓