DOAJ Open Access 2022

18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom

Andréa Vidal Ferreira Ana Carolina Araujo Bispo Christiane Silva Leite Juliana Batista da Silva Marcelo Mamede +2 lainnya

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Abstrak

Small animals, such as mice, are used in radiopharmaceutical biodistribution studies and innumerous others preclinical investigations involving ionizing radiation. Longitudinal preclinical studies with five or more image procedures, involving radiopharmaceuticals injection and/or X-radiation, are not uncommon. However, a suitable dosimetric evaluation is not always available and, sometimes, absorbed doses in animal organs or tissues and their influence in experimental results were not appropriately taken into account. Accurate calculation of absorbed doses in mice organs are needed to evaluate potential radiobiological effects that may interfere with in vivo experiments. In this work, we perform a preliminary 16α-[18F]-fluoro-17β-estradiol (18F-FES) radiation dosimetry estimates for female mice. The obtained animal dosimetric results can be useful for evaluating animal doses during the design of longitudinal preclinical studies.

Topik & Kata Kunci

Medical physics. Medical radiology. Nuclear medicine Radioactivity and radioactive substances

Penulis (7)

Andréa Vidal Ferreira

Ana Carolina Araujo Bispo

Christiane Silva Leite

Juliana Batista da Silva

Marcelo Mamede

Rodrigo Modesto Gadelha Gontijo

Bruno Melo Mendes

Format Sitasi

APA MLA BibTeX

Ferreira, A.V., Bispo, A.C.A., Leite, C.S., Silva, J.B.d., Mamede, M., Gontijo, R.M.G. et al. (2022). 18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom. https://doi.org/10.15392/2319-0612.2022.2089

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.15392/2319-0612.2022.2089
Akses: Open Access ✓