DOAJ Open Access 2024

Improved sensitivity bounds for mediation under unmeasured mediator–outcome confounding

Sjölander Arvid Waernbaum Ingeborg

Abstrak

It is often of interest to decompose a total effect into an indirect effect, relayed through a particular mediator, and a direct effect. However, these effect components are not identified if there are unmeasured confounding of the mediator and the outcome. We derive nonparametric bounds on the natural direct and indirect effects, and Cornfield inequalities that the unmeasured confounders must satisfy to explain away an “observed” effect. We demonstrate, analytically and by simulation, that these bounds and Cornfield inequalities are sharper than those previously proposed in the literature. We illustrate the methods with an application to cholestyramine treatment for coronary heart disease.

Topik & Kata Kunci

Mathematics Probabilities. Mathematical statistics

Penulis (2)

Sjölander Arvid

Waernbaum Ingeborg

Format Sitasi

APA MLA BibTeX

Arvid, S., Ingeborg, W. (2024). Improved sensitivity bounds for mediation under unmeasured mediator–outcome confounding. https://doi.org/10.1515/jci-2023-0070

Akses Cepat

PDF tidak tersedia langsung

Cek di sumber asli →

Lihat di Sumber doi.org/10.1515/jci-2023-0070

Informasi Jurnal

Tahun Terbit: 2024
Sumber Database: DOAJ
DOI: 10.1515/jci-2023-0070
Akses: Open Access ✓