DOAJ Open Access 2024

Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs.

Felix E Y Aggor Martinna Bertolini Bianca M Coleman Tiffany C Taylor Nicole O Ponde +1 lainnya

Abstrak

Oropharyngeal candidiasis (OPC) is the most common human fungal infection, arising typically from T cell immune impairments. IL-17 and IL-22 contribute individually to OPC responses, but here we demonstrate that the combined actions of both cytokines are essential for resistance to OPC. Mice lacking IL-17RA and IL-22RA1 exhibited high fungal loads in esophagus- and intestinal tract, severe weight loss, and symptoms of colitis. Ultimately, mice succumbed to infection. Dual loss of IL-17RA and IL-22RA impaired expression of small proline rich proteins (SPRRs), a class of antimicrobial effectors not previously linked to fungal immunity. Sprr2a1 exhibited direct candidacidal activity in vitro, and Sprr1-3a-/- mice were susceptible to OPC. Thus, cooperative actions of Type 17 cytokines mediate oral mucosal anti-Candida defenses and reveal a role for SPRRs.

Topik & Kata Kunci

Immunologic diseases. Allergy Biology (General)

Penulis (6)

Felix E Y Aggor

Martinna Bertolini

Bianca M Coleman

Tiffany C Taylor

Nicole O Ponde

Sarah L Gaffen

Format Sitasi

APA MLA BibTeX

Aggor, F.E.Y., Bertolini, M., Coleman, B.M., Taylor, T.C., Ponde, N.O., Gaffen, S.L. (2024). Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs.. https://doi.org/10.1371/journal.ppat.1012302

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Lihat di Sumber doi.org/10.1371/journal.ppat.1012302

Informasi Jurnal

Tahun Terbit: 2024
Sumber Database: DOAJ
DOI: 10.1371/journal.ppat.1012302
Akses: Open Access ✓