DOAJ Open Access 2012

Granulocyte-colony stimulating factor (G-CSF) improves motor recovery in the rat impactor model for spinal cord injury.

Tanjew Dittgen Claudia Pitzer Christian Plaas Friederike Kirsch Gerhard Vogt +2 lainnya

Abstrak

Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of the protein. To further broaden confidence in animal efficacy data we sought to determine efficacy in a different model and a different species. Here we investigated the effects of G-CSF in Wistar rats using the New York University Impactor. In this model, corroborating our previous data, rats treated subcutaneously with G-CSF over 2 weeks show significant improvement of motor function.

Topik & Kata Kunci

Medicine Science

Penulis (7)

Tanjew Dittgen

Claudia Pitzer

Christian Plaas

Friederike Kirsch

Gerhard Vogt

Rico Laage

Armin Schneider

Format Sitasi

APA MLA BibTeX

Dittgen, T., Pitzer, C., Plaas, C., Kirsch, F., Vogt, G., Laage, R. et al. (2012). Granulocyte-colony stimulating factor (G-CSF) improves motor recovery in the rat impactor model for spinal cord injury.. https://doi.org/10.1371/journal.pone.0029880

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Informasi Jurnal

Tahun Terbit: 2012
Sumber Database: DOAJ
DOI: 10.1371/journal.pone.0029880
Akses: Open Access ✓