DOAJ Open Access 2020

HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis

Guy Karlebach Peter Hansen Diogo FT Veiga Robin Steinhaus Daniel Danis +3 lainnya

Abstrak

Abstract We present Hierarchical Bayesian Analysis of Differential Expression and ALternative Splicing (HBA-DEALS), which simultaneously characterizes differential expression and splicing in cohorts. HBA-DEALS attains state of the art or better performance for both expression and splicing and allows genes to be characterized as having differential gene expression, differential alternative splicing, both, or neither. HBA-DEALS analysis of GTEx data demonstrated sets of genes that show predominant DGE or DAST across multiple tissue types. These sets have pervasive differences with respect to gene structure, function, membership in protein complexes, and promoter architecture.

Topik & Kata Kunci

Biology (General) Genetics

Penulis (8)

Guy Karlebach

Peter Hansen

Diogo FT Veiga

Robin Steinhaus

Daniel Danis

Sheng Li

Olga Anczukow

Peter N Robinson

Format Sitasi

APA MLA BibTeX

Karlebach, G., Hansen, P., Veiga, D.F., Steinhaus, R., Danis, D., Li, S. et al. (2020). HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis. https://doi.org/10.1186/s13059-020-02072-6

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Informasi Jurnal

Tahun Terbit: 2020
Sumber Database: DOAJ
DOI: 10.1186/s13059-020-02072-6
Akses: Open Access ✓