DOAJ Open Access 2025

Gut microbiota and kidney aging: insights into current research

Yalda Rahbar Saadat Abolfazl Barzegari Zahra Saadatian Soheila Montazersaheb Sepideh Zununi Vahed

Abstrak

Abstract Aging induces structural and functional alterations in the kidneys, including changes in renal morphology and progressive decline in renal function. During aging, the gut microbiota undergoes profound shifts in composition and activity, transitioning from predominantly commensal to more pathogenic communities. Renal dysfunction further exacerbates this process by reducing toxin clearance and promoting the accumulation of uremic metabolites, which disrupt gut microbial balance. In turn, gut dysbiosis impairs kidney function, creating a self-perpetuating cycle of microbial imbalance and renal damage. Hence, breaking this vicious cycle of dysbiosis and kidney damage is important. This review sheds light on the bidirectional relationship between gut microbiota and kidney aging. It also highlights the potential of microbiota-targeted interventions to restore microbial balance and delay the onset of age-related issues.

Topik & Kata Kunci

Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases

Penulis (5)

Yalda Rahbar Saadat

Abolfazl Barzegari

Zahra Saadatian

Soheila Montazersaheb

Sepideh Zununi Vahed

Format Sitasi

APA MLA BibTeX

Saadat, Y.R., Barzegari, A., Saadatian, Z., Montazersaheb, S., Vahed, S.Z. (2025). Gut microbiota and kidney aging: insights into current research. https://doi.org/10.1186/s12986-025-01032-w

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1186/s12986-025-01032-w
Akses: Open Access ✓