FOLR2+ macrophages in cancer: allies or enemies
Abstrak
Abstract The advent of the omics era has facilitated the identification of precise biomarkers for cancer progression, revealing a broader diversity of macrophage phenotypes beyond the traditional M1/M2 classification. Folate receptor 2 (FOLR2)-positive macrophages, co-expressing markers such as mannose receptor C-Type 1 (MRC1/CD206) and lymphatic vessel endothelial hyaluronan receptor 1(LYVE1), are an embryonically derived subset typically found around blood vessels in both tumor stroma and normal tissues. Despite FOLR2’s longstanding association with anti-inflammatory, immunosuppressive macrophages in tumors, its precise role in cancer progression remains unclear. Recent studies suggest that FOLR2+ macrophages can either promote or inhibit cancer progression, depending on their multifaceted roles in the tumor microenvironment. This review provides a comprehensive overview of the biological features, functional roles, molecular mechanisms, and therapeutic potential of FOLR2+ macrophages in cancer.
Penulis (10)
Decheng Jiang
Ruiling Xiao
Jialu Bai
Xing Wang
Yuan Fang
Jianzhou Liu
Xiaohan Wang
Ming Cui
Lei You
Yupei Zhao
Akses Cepat
- Tahun Terbit
- 2025
- Sumber Database
- DOAJ
- DOI
- 10.1186/s12964-025-02257-1
- Akses
- Open Access ✓