DOAJ Open Access 2024

Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage

Xiaolong Tang Xinyu Yang Yamei Yu Miaojing Wu Yuanyuan Li +7 lainnya

Abstrak

Abstract After intracerebral hemorrhage (ICH) occurs, the overproduction of reactive oxygen species (ROS) and iron ion overload are the leading causes of secondary damage. Removing excess iron ions and ROS in the meningeal system can effectively alleviate the secondary damage after ICH. This study synthesized ginsenoside Rb1 carbon quantum dots (RBCQDs) using ginsenoside Rb1 and ethylenediamine via a hydrothermal method. RBCQDs exhibit potent capabilities in scavenging ABTS + free radicals and iron ions in solution. After intrathecal injection, the distribution of RBCQDs is predominantly localized in the subarachnoid space. RBCQDs can eliminate ROS and chelate iron ions within the meningeal system. Treatment with RBCQDs significantly improves blood flow in the meningeal system, effectively protecting dying neurons, improving neurological function, and providing a new therapeutic approach for the clinical treatment of ICH.

Topik & Kata Kunci

Biotechnology Medical technology

Penulis (12)

Xiaolong Tang

Xinyu Yang

Yamei Yu

Miaojing Wu

Yuanyuan Li

Zhe Zhang

Guangyu Jia

Qi Wang

Wei Tu

Ye Wang

Xingen Zhu

Shiyong Li

Format Sitasi

APA MLA BibTeX

Tang, X., Yang, X., Yu, Y., Wu, M., Li, Y., Zhang, Z. et al. (2024). Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage. https://doi.org/10.1186/s12951-024-02368-w

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Informasi Jurnal

Tahun Terbit: 2024
Sumber Database: DOAJ
DOI: 10.1186/s12951-024-02368-w
Akses: Open Access ✓