DOAJ Open Access 2023

Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance

Gaetano Scaramuzzo Francesco Nucera Alessio Asmundo Roberto Messina Matilde Mari +14 lainnya

Abstrak

Abstract The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support. The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.

Topik & Kata Kunci

Therapeutics. Pharmacology

Penulis (19)

Gaetano Scaramuzzo

Francesco Nucera

Alessio Asmundo

Roberto Messina

Matilde Mari

Federica Montanaro

Matt D. Johansen

Francesco Monaco

Guido Fadda

Giovanni Tuccari

Nicole G. Hansbro

Philip M. Hansbro

Trevor T. Hansel

Ian M. Adcock

Antonio David

Paul Kirkham

Gaetano Caramori

Carlo Alberto Volta

Savino Spadaro

Format Sitasi

APA MLA BibTeX

Scaramuzzo, G., Nucera, F., Asmundo, A., Messina, R., Mari, M., Montanaro, F. et al. (2023). Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance. https://doi.org/10.1186/s12950-023-00333-2

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.1186/s12950-023-00333-2
Akses: Open Access ✓