DOAJ Open Access 2025

Intracellular cholesterol: new functions and therapeutic approaches in NSCLC EGFR-TKI resistance

Linjuan Wang Yue Qiu Xiang Huang Shimei Zhang Min Zhao +1 lainnya

Abstrak

Abstract Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly enhanced survival rates among patients with advanced non-small cell lung cancer (NSCLC) exhibiting EGFR mutations. However, acquired resistance diminishes their therapeutic efficacy over time. Recent investigations have linked intracellular cholesterol with the emergence and advancement of various cancers. Elevated cholesterol levels could correlate with resistance to EGFR-TKIs in NSCLC. This review examines the association between cholesterol and EGFR-TKI resistance in NSCLC, with the objective of identifying more effective treatments and surmounting resistance.

Topik & Kata Kunci

Nutritional diseases. Deficiency diseases

Penulis (6)

Linjuan Wang

Yue Qiu

Xiang Huang

Shimei Zhang

Min Zhao

Qiufang Chen

Format Sitasi

APA MLA BibTeX

Wang, L., Qiu, Y., Huang, X., Zhang, S., Zhao, M., Chen, Q. (2025). Intracellular cholesterol: new functions and therapeutic approaches in NSCLC EGFR-TKI resistance. https://doi.org/10.1186/s12944-025-02559-w

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Lihat di Sumber doi.org/10.1186/s12944-025-02559-w

Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1186/s12944-025-02559-w
Akses: Open Access ✓