DOAJ Open Access 2018

PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report

Jonathan W. Goldman Basmah Abdalla Melody A. Mendenhall Anthony Sisk Jaime Hunt +2 lainnya

Abstrak

Abstract Background The management of malignancy post kidney transplantation includes reduction in immunosuppression and referral to an oncologist management of their malignancy. Recent advances in oncology have resulted in the approval of several classes of drugs with immune-modulatory activity. However, activation of the immune system against malignant cells may precipitate allograft rejection in solid organ transplant recipients. Case presentation Herein we present a case of acute kidney allograft rejection in a 50 year old man following administration of the novel immune-modulatory agent nivolumab for the treatment of metastatic squamous cell carcinoma. Conclusion The management of malignancy in solid organ transplant recipients requires a heightened awareness of the potential for allograft rejection in this new era of cancer therapeutics.

Topik & Kata Kunci

Diseases of the genitourinary system. Urology

Penulis (7)

Jonathan W. Goldman

Basmah Abdalla

Melody A. Mendenhall

Anthony Sisk

Jaime Hunt

Gabriel M. Danovitch

Erik L. Lum

Format Sitasi

APA MLA BibTeX

Goldman, J.W., Abdalla, B., Mendenhall, M.A., Sisk, A., Hunt, J., Danovitch, G.M. et al. (2018). PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin – case report. https://doi.org/10.1186/s12882-018-1003-5

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Informasi Jurnal

Tahun Terbit: 2018
Sumber Database: DOAJ
DOI: 10.1186/s12882-018-1003-5
Akses: Open Access ✓