DOAJ Open Access 2023

Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP

Hoda Ranjbar Monavareh Soti Kristi A. Kohlmeier Mahyar Janahmadi Mohammad Shabani

Abstrak

Highlights Purkinje cell excitability dramatically increased after exposure to 3-AP. 3-AP caused a significant decrease in ISI, half-width, and first spike latency. CB1R antagonist attenuated the cellular effects of 3-AP. AM251 reduced the excitability of Purkinje cells exposed to 3-AP.

Topik & Kata Kunci

Neurosciences. Biological psychiatry. Neuropsychiatry Neurophysiology and neuropsychology

Penulis (5)

Hoda Ranjbar

Monavareh Soti

Kristi A. Kohlmeier

Mahyar Janahmadi

Mohammad Shabani

Format Sitasi

APA MLA BibTeX

Ranjbar, H., Soti, M., Kohlmeier, K.A., Janahmadi, M., Shabani, M. (2023). Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP. https://doi.org/10.1186/s12868-023-00786-4

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.1186/s12868-023-00786-4
Akses: Open Access ✓