DOAJ Open Access 2022

CircPrimer 2.0: a software for annotating circRNAs and predicting translation potential of circRNAs

Shanliang Zhong Jifeng Feng

Abstrak

Abstract Background Some circular RNAs (circRNAs) can be translated into functional peptides by small open reading frames (ORFs) in a cap-independent manner. Internal ribosomal entry site (IRES) and N6-methyladenosine (m6A) were reported to drive translation of circRNAs. Experimental methods confirming the presence of IRES and m6A site are time consuming and labor intensive. Lacking computational tools to predict ORFs, IRESs and m6A sites for circRNAs makes it harder. Results In this report, we present circPrimer 2.0, a Java based software for annotating circRNAs and predicting ORFs, IRESs, and m6A sites of circRNAs. circPrimer 2.0 has a graphical and a command-line interface that enables the tool to be embed into an analysis pipeline. Conclusions circprimer 2.0 is an easy-to-use software for annotating circRNAs and predicting translation potential of circRNAs, and freely available at www.bio-inf.cn .

Topik & Kata Kunci

Computer applications to medicine. Medical informatics Biology (General)

Penulis (2)

Shanliang Zhong

Jifeng Feng

Format Sitasi

APA MLA BibTeX

Zhong, S., Feng, J. (2022). CircPrimer 2.0: a software for annotating circRNAs and predicting translation potential of circRNAs. https://doi.org/10.1186/s12859-022-04705-y

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.1186/s12859-022-04705-y
Akses: Open Access ✓