DOAJ Open Access 2023

Comparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes?

Silvia Berkner Ute Brandt

Abstrak

Abstract Information on transformation and persistence of chemical substances in the environment is important for hazard and risk assessment within a regulatory context or as a decision criterion in a safe and sustainable by design framework. Half-lives for human and veterinary medicinal products available from marketing authorization applications were compared between soil (OECD 307) and aquatic water/sediment systems (OECD 308). The comparison shows, that there is no obvious correlation between the total system half-lives in the two different compartments and that surpassing persistence criteria is compartment-specific in 45% of the cases.

Topik & Kata Kunci

Environmental sciences Environmental law

Penulis (2)

Silvia Berkner

Ute Brandt

Format Sitasi

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Berkner, S., Brandt, U. (2023). Comparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes?. https://doi.org/10.1186/s12302-023-00783-8

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.1186/s12302-023-00783-8
Akses: Open Access ✓