DOAJ Open Access 2022

LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter

Si-Li He Ya-Ling Chen Qi-Hua Chen Qi Tian Shui-Jing Yi

Abstrak

Highlights 1. LncRNA KCNQ1OT1 is upregulated, while EIF2B5 is downregulated in OC tissues and cells. 2. Knockdown of KCNQ1OT1 represses OC cell proliferation and metastasis. 3. KCNQ1OT1 decreases EIF2B5 expression by recruiting DNA methyltransferases into EIF2B5 promoter, thereby promoting OC progression.

Topik & Kata Kunci

Therapeutics. Pharmacology Biochemistry

Penulis (5)

Si-Li He

Ya-Ling Chen

Qi-Hua Chen

Qi Tian

Shui-Jing Yi

Format Sitasi

APA MLA BibTeX

He, S., Chen, Y., Chen, Q., Tian, Q., Yi, S. (2022). LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter. https://doi.org/10.1186/s10020-022-00521-5

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.1186/s10020-022-00521-5
Akses: Open Access ✓