Biodistribution and clearance of instilled carbon nanotubes in rat lung
Abstrak
<p>Abstract</p> <p>Background</p> <p>Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex.</p> <p>Methods</p> <p>We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated.</p> <p>Results and conclusion</p> <p>Our results in rats that received MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration.</p>
Topik & Kata Kunci
Penulis (9)
Rogerieux Françoise
Delalain Patrice
Gamez Christelle
Meunier Laurent
Abella-Gallart Steve
Floriani Magali
Elgrabli Dan
Boczkowski Jorge
Lacroix Ghislaine
Akses Cepat
- Tahun Terbit
- 2008
- Sumber Database
- DOAJ
- DOI
- 10.1186/1743-8977-5-20
- Akses
- Open Access ✓