Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
Abstrak
<p>Abstract</p> <p>Background</p> <p>The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced.</p> <p>Results</p> <p>In the current study we inferred the migration history of HIV-1 subtype B by way of a phylogeography of viral sequences sampled from 16 European countries and Israel. Migration events were inferred from viral phylogenies by character reconstruction using parsimony. With regard to the spatial dispersal of the HIV subtype B sequences across viral phylogenies, in most of the countries in Europe the epidemic was introduced by multiple sources and subsequently spread within local networks. Poland provides an exception where most of the infections were the result of a single point introduction. According to the significant migratory pathways, we show that there are considerable differences across Europe. Specifically, Greece, Portugal, Serbia and Spain, provide sources shedding HIV-1; Austria, Belgium and Luxembourg, on the other hand, are migratory targets, while for Denmark, Germany, Italy, Israel, Norway, the Netherlands, Sweden, Switzerland and the UK we inferred significant bidirectional migration. For Poland no significant migratory pathways were inferred.</p> <p>Conclusion</p> <p>Subtype B phylogeographies provide a new insight about the geographical distribution of viral lineages, as well as the significant pathways of virus dispersal across Europe, suggesting that intervention strategies should also address tourists, travellers and migrants.</p>
Topik & Kata Kunci
Penulis (48)
Perrin Luc
Ormaasen Vidar
Op de Coul Eline LM
Meyer Laurence
Nielsen Claus
Maljkovic-Berry I
MacRae Eilidh
Loveday Clive
Leitner Thomas
Korn Klaus
Kücherer Claudia
Horban Andrzej
Hoepelman IM
Hamouda Osama
Grossman Zehava
de Mendoza Carmen
Derdelinckx Inge
De Luca Andrea
Costagliola Dominique
Coughlan Suzie
Chaix Marie-Laure
Camacho Ricardo
Boeri Enzo
Balotta Claudia
Åsjö Birgitta
Angarano Guiseppe
Albert Jan
van de Vijver David A
Wensing Annemarie MJ
Hatzakis Angelos
Magiorkinis Gkikas
Pybus Oliver
Paraskevis Dimitrios
Puchhammer-Stöckl Elisabeth
Ruiz Lidia
Salminen Mika O
Schmit Jean-Claude
Schuurman Rob
Soriano Vincent
Stanczak J
Stanojevic Maja
Struck Daniel
Van Laethem Kristel
Violin M
Yerly Sabine
Zazzi Maurizio
Boucher Charles A
Vandamme Anne-Mieke
Akses Cepat
- Tahun Terbit
- 2009
- Sumber Database
- DOAJ
- DOI
- 10.1186/1742-4690-6-49
- Akses
- Open Access ✓