DOAJ Open Access 2022

Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy

Jinhua Chen Zhenhua Yin Wenping Song Baoxia He Wenzhou Zhang

Abstrak

Accumulating evidence has showed that sushi-repeat-containing protein X-linked 2 (SRPX2) is an abnormal expression in a variety of cancers and involved in cancer carcinogenesis, chemosensitivity, and prognosis, which mainly promote cancer cell metastasis, invasion, and migration by regulating the uPAR/integrins/FAK signaling pathway, epithelial-mesenchymal transition (EMT), angiogenesis, and glycosylation. Inflammation has been regarded as a key role in regulating cancer initiation, progression, EMT, and therapeutics. Furthermore, SRPX2 exhibited excellent antifibrosis effect via the TGFβR1/SMAD3/SRPX2/AP1/SMAD7 signaling pathway. Therefore, this review provides compelling evidence that SRPX2 might be a therapeutic target for inflammation and cancer-related inflammation for future cancer therapeutics.

Topik & Kata Kunci

Immunologic diseases. Allergy

Penulis (5)

Jinhua Chen

Zhenhua Yin

Wenping Song

Baoxia He

Wenzhou Zhang

Format Sitasi

APA MLA BibTeX

Chen, J., Yin, Z., Song, W., He, B., Zhang, W. (2022). Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy. https://doi.org/10.1155/2022/2931214

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Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.1155/2022/2931214
Akses: Open Access ✓