DOAJ Open Access 2020

Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers

Rui Wei Si Liu Shutian Zhang Li Min Shengtao Zhu

Abstrak

Tumors are surrounded by complex environmental components, including blood and lymph vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and extracellular matrix. All the stromal components together with the tumor cells form the tumor microenvironment (TME). In addition, extracellular physical and chemical factors, including extracellular pH, hypoxia, elevated interstitial fluid pressure, and fibrosis, are closely associated with tumor progression, metastasis, immunosuppression, and drug resistance. Cellular and extracellular components in TME contribute to nearly all procedures of carcinogenesis. By summarizing the recent work in this field, we make a comprehensive review on the role of cellular and extracellular components in the process of carcinogenesis and their potential application in early diagnosis of cancer. We hope that a systematic review of the diverse aspects of TME will help both research scientists and clinicians in this field.

Topik & Kata Kunci

Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology

Penulis (5)

Rui Wei

Si Liu

Shutian Zhang

Li Min

Shengtao Zhu

Format Sitasi

APA MLA BibTeX

Wei, R., Liu, S., Zhang, S., Min, L., Zhu, S. (2020). Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers. https://doi.org/10.1155/2020/6283796

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Informasi Jurnal

Tahun Terbit: 2020
Sumber Database: DOAJ
DOI: 10.1155/2020/6283796
Akses: Open Access ✓