Immunophenotype Heterogeneity in Nasal Glomangiopericytoma
Abstrak
Nasal glomangiopericytoma is rare. The immunophenotype is heterogeneous, more frequently smooth-muscle-actin and CD34-positive. We report expression patterns for several vascular-related proteins such as CD99, CD146, Bcl2, and WT1 as well as for treatment-related proteins such as mTOR and EGFR in a nasal glomangiopericytoma. The patient (woman, 86 years) presented with a left nasal tumefaction. The resected specimen (1.5-cm) showed a glomangiopericytoma. Tumor cells expressed smooth-muscle-actin, CD31, CD34, and progesterone receptor. They also expressed the vascular-cell-related proteins Bcl2, CD99, CD146, and WT1, as well as mTOR and EGFR. Nasal glomangiopericytomas show immunohistochemical heterogeneity for vascular-related markers, suggesting a possible extensive pericytic differentiation. The expression of potential targets for drug treatments such as mTOR and EGFR may impact on the clinical follow-up of these tumors occurring at advanced ages, which may require complex surgery.
Topik & Kata Kunci
Penulis (4)
Adriana Handra-Luca
Zakaria Y. Abd Elmageed
Christina Magkou
Marick Lae
Akses Cepat
- Tahun Terbit
- 2015
- Sumber Database
- DOAJ
- DOI
- 10.1155/2015/308743
- Akses
- Open Access ✓