Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease
Abstrak
The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease. The present retrospective pair-matched study included 560 patients, grouped according to whether or not they received AST-120 before dialysis (AST-120 and non-AST-120 groups). The cumulative dialysis initiation free rate and survival rate were compared by the Kaplan-Meier method. Multivariate analysis was used to determine the impact of AST-120 on dialysis initiation. Our results showed significant differences in the 12- and 24-month dialysis initiation free rate (P<0.001), although no significant difference was observed in the survival rate between the two groups. In conclusion, AST-120 delays dialysis initiation in chronic kidney disease (CKD) patients but has no effect on survival. AST-120 is an effective therapy for delaying the progression of CKD.
Topik & Kata Kunci
Penulis (17)
Shingo Hatakeyama
Hayato Yamamoto
Akiko Okamoto
Kengo Imanishi
Noriko Tokui
Teppei Okamoto
Yuichiro Suzuki
Naoaki Sugiyama
Atsushi Imai
Shigemasa Kudo
Takahiro Yoneyama
Yasuhiro Hashimoto
Takuya Koie
Noritaka Kaminura
Hisao Saitoh
Tomihisa Funyu
Chikara Ohyama
Akses Cepat
- Tahun Terbit
- 2012
- Sumber Database
- DOAJ
- DOI
- 10.1155/2012/376128
- Akses
- Open Access ✓