DOAJ Open Access 2021

Label-Free Detection of Morpholino-DNA Hybridization Using a Silicon Photonics Suspended Slab Micro-Ring Resonator

Soha Yousuf Jongmin Kim Ajymurat Orozaliev Marcus S. Dahlem Yong-Ak Song +1 lainnya

Abstrak

In this study, deoxyribonucleic acid (DNA) hybridization was demonstrated using a suspended silicon photonics micro-ring resonator with a 90 nm-thick slab and morpholino as the capture probe. Complementary DNA of various concentrations were tested achieving a surface sensitivity of 2.12 nm/nM, a detection limit of 250 pM, and an intrinsic detection limit of 36.9 pM. A bulk sensitivity of 98 nm/RIU and an intrinsic detection limit of <inline-formula><tex-math notation="LaTeX">$1.03\times 10^{-3}$</tex-math></inline-formula> RIU was also measured upon exposure to isopropanol/deionized water solutions. With these characteristics, the suspended 90 nm slab ring sensor proved as a promising candidate for lab-on-a-chip bio-sensing applications.

Topik & Kata Kunci

Applied optics. Photonics Optics. Light

Penulis (6)

Soha Yousuf

Jongmin Kim

Ajymurat Orozaliev

Marcus S. Dahlem

Yong-Ak Song

Jaime Viegas

Format Sitasi

APA MLA BibTeX

Yousuf, S., Kim, J., Orozaliev, A., Dahlem, M.S., Song, Y., Viegas, J. (2021). Label-Free Detection of Morpholino-DNA Hybridization Using a Silicon Photonics Suspended Slab Micro-Ring Resonator. https://doi.org/10.1109/JPHOT.2021.3098680

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Informasi Jurnal

Tahun Terbit: 2021
Sumber Database: DOAJ
DOI: 10.1109/JPHOT.2021.3098680
Akses: Open Access ✓