DOAJ Open Access 2024

Discovery of Amphoteric Fingerprints of Amino Acids With Field-Effect Transistors

Naveen Kumar Rakshita Pritam Singh Dhar Janwa El Maiss Vihar Georgiev Cesar Pascual Garcia

Abstrak

When working with a few molecules, the existing protein sequencing technologies lack the single-site amino acid (AA) precision required to detect abnormalities that escape genome analysis. We offer a new method for identifying AAs and short polypeptides using the signal from the surface potential and capacitance obtained from Field Effect Transistor (FET) sensors. Using a combination of the Site-binding and Gouy-Chapman-Stern (GCS) models, we found the signatures of every single AA and polypeptides. These fingerprints are based on orthogonal features such as the proton dissociation constants of each AA’s charging sites, the dielectric constant, and the effective length.

Topik & Kata Kunci

Electrical engineering. Electronics. Nuclear engineering

Penulis (5)

Naveen Kumar

Rakshita Pritam Singh Dhar

Janwa El Maiss

Vihar Georgiev

Cesar Pascual Garcia

Format Sitasi

APA MLA BibTeX

Kumar, N., Dhar, R.P.S., Maiss, J.E., Georgiev, V., Garcia, C.P. (2024). Discovery of Amphoteric Fingerprints of Amino Acids With Field-Effect Transistors. https://doi.org/10.1109/ACCESS.2024.3411168

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Informasi Jurnal

Tahun Terbit: 2024
Sumber Database: DOAJ
DOI: 10.1109/ACCESS.2024.3411168
Akses: Open Access ✓