DOAJ Open Access 2021

Vitamin C-Induced Oxalate Nephropathy in a Septic Patient

Tasheen Wissanji, MD, FRCPC Marie-Eve Dupuis, MD Virginie Royal, MD Vincent Pichette, MD Han Ting Wang, MD, FRCPC

Abstrak

OBJECTIVES:. Vitamin C is a novel treatment currently under investigation in the management of sepsis. Adverse renal effects of vitamin C through hyperoxaluria have been described in the past. DATA SOURCES:. We report the case of a 63-year-old man admitted in a community-based hospital with a diagnosis of sepsis of pulmonary origin. DATA EXTRACTION:. On day 19, despite a having developed oligoanuric acute kidney injury, a regimen of IV vitamin C, hydrocortisone, and thiamine was undertaken for 4 days. On day 23, the patient required renal replacement therapy with an estimated glomerular filtration rate of 7 mL/min. Renal biopsy revealed extensive acute tubular necrosis associated with the presence of intratubular crystal of calcium oxalate. Conclusion:. Although vitamin C seems to be a possible therapeutic asset in the supportive care of sepsis patients, larger cohorts are required to ensure its safety and underlying or novel kidney injury should forewarn clinicians as to its use.

Topik & Kata Kunci

Medical emergencies. Critical care. Intensive care. First aid

Penulis (5)

Tasheen Wissanji, MD, FRCPC

Marie-Eve Dupuis, MD

Virginie Royal, MD

Vincent Pichette, MD

Han Ting Wang, MD, FRCPC

Format Sitasi

APA MLA BibTeX

FRCPC, T.W.M., MD, M.D., MD, V.R., MD, V.P., FRCPC, H.T.W.M. (2021). Vitamin C-Induced Oxalate Nephropathy in a Septic Patient. https://doi.org/10.1097/CCE.0000000000000389

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Informasi Jurnal

Tahun Terbit: 2021
Sumber Database: DOAJ
DOI: 10.1097/CCE.0000000000000389
Akses: Open Access ✓