DOAJ Open Access 2022

SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case

Olgo A. Mukhina Daria S. Fomina Vasiliy V. Parshin Vladimir A. Gushchin Inna V. Dolzhikova +8 lainnya

Lihat Sumber DOI

Abstrak

The article highlights the course of long-term SARS-CoV-2 infection in a patient with a secondary immunodeficiency developed with B-cell-depleting therapy of the underlying disease. Analysis of the intrapatient virus evolution revealed an inpatient S:G75A mutation that alters the 72GTNGTKR78 motif of the S-protein, with a possible role in binding to alternative cellular receptors. Therapy with a ready-made COVID-19-globulin preparation (native human immunoglobulin G (IgG) derived from the plasma of convalescent COVID-19-patients) resulted in rapid improvement of the patient’s condition, fast, and stable elimination of the virus, and passive immunization of the patient for at least 30 days. The results suggest the use of products containing neutralizing antibodies opens new prospects for treatment algorithms for patients with persistent coronavirus infection, as well as for passive immunization schemes for patients with a presumably reduced specific response to vaccination.

Topik & Kata Kunci

Immunologic diseases. Allergy Therapeutics. Pharmacology

Penulis (13)

Olgo A. Mukhina

Daria S. Fomina

Vasiliy V. Parshin

Vladimir A. Gushchin

Inna V. Dolzhikova

Alexey M. Shchetinin

Dmitriy M. Chudakov

Evgeniia Alekseeva

Dmitriy Korostin

Georgii A. Bazykin

Galya Klink

Denis Yu. Logunov

Maryana A. Lysenko

Format Sitasi

APA MLA BibTeX

Mukhina, O.A., Fomina, D.S., Parshin, V.V., Gushchin, V.A., Dolzhikova, I.V., Shchetinin, A.M. et al. (2022). SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case. https://doi.org/10.1080/21645515.2022.2101334

Akses Cepat

Lihat di Sumber doi.org/10.1080/21645515.2022.2101334

Informasi Jurnal

Tahun Terbit: 2022
Sumber Database: DOAJ
DOI: 10.1080/21645515.2022.2101334
Akses: Open Access ✓