Quantifying antibody binding: techniques and therapeutic implications
Abstrak
The binding kinetics of an antibody for its target antigen represent key determinants of its biological function and success as a novel biotherapeutic. Defining these interactions and kinetics is critical for understanding the pharmacological and pharmacodynamic profiles of antibodies in therapeutic applications, with line of sight to clinical translation. In this review, we discuss the latest developments in approaches to measure and modulate antibody-antigen interactions, including antibody engineering, novel antibody formats, current, and emerging technologies for measuring antibody-antigen binding interactions, and emerging perspectives within the field. We also explore how emerging computational methods are set to become powerful tools for modeling antibody-binding interactions under physiologically relevant conditions. Finally, we consider the therapeutic implications of modulating target engagement in terms of pharmacodynamics and pharmacokinetics.
Topik & Kata Kunci
Penulis (8)
James Lodge
Lewis Kajtar
Rachel Duxbury
David Hall
Glenn A. Burley
Joanna Cordy
James W.T. Yates
Zahra Rattray
Akses Cepat
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Cek di sumber asli →- Tahun Terbit
- 2025
- Sumber Database
- DOAJ
- DOI
- 10.1080/19420862.2025.2459795
- Akses
- Open Access ✓