DOAJ Open Access 2025

The intersection of aging and estrogen in osteoarthritis

Aysegul Atasoy-Zeybek Kelly K. Showel Christopher V. Nagelli Jennifer J. Westendorf Christopher H. Evans

Abstrak

Abstract Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degradation, inflammation, and pain. While multiple factors contribute to OA development, age and sex are primary risk factors, particularly affecting postmenopausal women. The dramatic increase in OA risk after menopause suggests estrogen deficiency accelerates disease progression. This review explores the molecular mechanisms connecting aging and estrogen deficiency in OA development, focusing on key genes and pathways identified through RNA sequencing.

Topik & Kata Kunci

Women. Feminism Medicine (General) Biology (General)

Penulis (5)

Aysegul Atasoy-Zeybek

Kelly K. Showel

Christopher V. Nagelli

Jennifer J. Westendorf

Christopher H. Evans

Format Sitasi

APA MLA BibTeX

Atasoy-Zeybek, A., Showel, K.K., Nagelli, C.V., Westendorf, J.J., Evans, C.H. (2025). The intersection of aging and estrogen in osteoarthritis. https://doi.org/10.1038/s44294-025-00063-1

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Informasi Jurnal

Tahun Terbit: 2025
Sumber Database: DOAJ
DOI: 10.1038/s44294-025-00063-1
Akses: Open Access ✓