DOAJ Open Access 2023

The anticancer mechanisms of exopolysaccharide from Weissella cibaria D-2 on colorectal cancer via apoptosis induction

Yurong Du Lei Liu Weiliang Yan Yang Li Yuanzhe Li +9 lainnya

Abstrak

Abstract Exopolysaccharide (EPS) from Weissella cibaria has been devoted to the study of food industry. However, the anticancer activity of W. cibaria derived EPS has not yet been investigated. In this study, we obtained the EPS from W. cibaria D-2 isolated from the feces of healthy infants and found that D-2-EPS, a homopolysaccharide with porous web like structure, could effectively inhibit the proliferation, migration, invasion and induce cell cycle arrest in G0/G1 phase of colorectal cancer (CRC) cells. In HT-29 tumor xenografts, D-2-EPS significantly retarded tumor growth without obvious cytotoxicity to normal organs. Furthermore, we revealed that D-2-EPS promoted the apoptosis of CRC cells by increasing the levels of Fas, FasL and activating Caspase-8/Caspase-3, indicating that D-2-EPS might induce apoptosis through the extrinsic Fas/FasL pathway. Taken together, the D-2-EPS has the potential to be developed as a nutraceutical or drug to prevent and treat colorectal cancer.

Topik & Kata Kunci

Medicine Science

Penulis (14)

Yurong Du

Lei Liu

Weiliang Yan

Yang Li

Yuanzhe Li

Kang Cui

Pu Yu

Zhuoyu Gu

WanCun Zhang

Jianguo Feng

Zhen Li

Hao Tang

Yabing Du

Huan Zhao

Format Sitasi

APA MLA BibTeX

Du, Y., Liu, L., Yan, W., Li, Y., Li, Y., Cui, K. et al. (2023). The anticancer mechanisms of exopolysaccharide from Weissella cibaria D-2 on colorectal cancer via apoptosis induction. https://doi.org/10.1038/s41598-023-47943-7

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Informasi Jurnal

Tahun Terbit: 2023
Sumber Database: DOAJ
DOI: 10.1038/s41598-023-47943-7
Akses: Open Access ✓